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Recent advances in tenuazonic acid as a potential herbicide

Recent advances in tenuazonic acid as a potential herbicide

Shiguo Chen, Sheng Qiang,

Weed Research Laboratory, Nanjing Agricultural University, Nanjing 210095, China
Received 19 September 2016, Revised 27 December 2016, Accepted 3 January 2017, Available online 4 January 2017
http://dx.doi.org/10.1016/j.pestbp.2017.01.003


Abstract:Tenuazonic acid (TeA), belonging to tetramic acids that are the largest family of natural products, is a mycotoxin produced by members of the genus Alternaria and other phytopathogenic fungi. TeA has many desirable bioactivities. In the past two decades, several studies have addressed its phytotoxic activity. Because it can cause brown leaf spot and kill seedlings of mono- and dicotyledonous plants, TeA is regarded as a potential herbicidal agent. TeA blocks electron transport beyond QA by interacting with D1 protein and is a PSII inhibitor. The chloroplast-derived oxidative burst is responsible for TeA-induced cell death and plant necrosis. Based on the model of molecular interaction between TeA and D1 protein, a series of its derivatives with stable herbicidal activity have been designed, evaluated and patented. Recently, some chemical synthetic approaches of TeA and its derivatives have been successfully developed. This paper will mainly focus on new developments regarding TeA's herbicidal activity, mode of action, biosynthesis and chemical synthesis, and characterization of new derivatives.


Highlights

It proposed the potential of TeA as a herbicidal agent.
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It presented the mode of action of TeA.
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It summarized the biosynthesis pathways and chemical synthesis methods of TeA.
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It highlighted the opportunities and challenges for the development of TeA and its derivatives as herbicides.


Keywords:Mycotoxin; Tetramic acid; Mode of action; Bioherbicide

原文连接:http://www.sciencedirect.com/science/article/pii/S0048357517300056